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An Open-Label, Dose-Finding Study of Vedolizumab IV for Treatment of Steroid-Refractory Acute Intestinal Graft-Versus-Host Disease (GvHD) in Patients Who Have Undergone Allogeneic Hematopoietic Stem Cell Transplantation (Allo-HSCT)

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An Open-Label, Dose-Finding Study of Vedolizumab IV for Treatment of Steroid-Refractory Acute Intestinal Graft-Versus-Host Disease (GvHD) in Patients Who Have Undergone Allogeneic Hematopoietic Stem Cell Transplantation (Allo-HSCT)

Status: Discontinued
Phase of Trial: Phase II

Latest Information Update: 17 Sep 2021

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At a glance

  • Drugs Vedolizumab (Primary)
  • Indications Graft-versus-host disease
  • Focus Adverse reactions; Proof of concept; Therapeutic Use
  • Sponsors Takeda Oncology

    • Most Recent Events

    • 09 Jun 2021 Primary endpoint (Percentage of Participants With Overall Response (Partial Response [PR]+Very Good Partial Response [VGPR]+Complete Response [CR]) at Day 28) has not been met, as results published in the Bone Marrow Transplantation.
    • 09 Jun 2021 Results published in the Bone Marrow Transplantation
    • 26 Jun 2018 Status changed from recruiting to discontinued.

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