Trial Profile

HyPeR: A Phase 1, Dose Escalation Study of Guadecitabine /ASTX727 in Combination With Pembrolizumab (MK3475) in Patients With Refractory Solid Tumours

Status: Active, no longer recruiting

Phase of Trial: Phase I

Latest Information Update: 15 May 2026

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At a glance

Drugs Guadecitabine (Primary) ; Pembrolizumab (Primary)
Indications Non-small cell lung cancer; Prostate cancer; Solid tumours
Focus Adverse reactions
Acronyms HyPeR

Most Recent Events

12 May 2026 Status changed from recruiting to active, no longer recruiting.
17 Aug 2025 Planned number of patients changed from 34 to 60.
19 Mar 2024 Status has been to recruiting.

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