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Colorectal Cancer Metastatic dMMR/MSI-H Immuno-Therapy (COMMIT) Study: A Randomized Phase III Study of mFOLFOX6/Bevacizumab/Atezolizumab Combination Versus Single Agent Atezolizumab in the First-Line Treatment of Patients With Deficient DNA Mismatch Repair (dMMR)/Microsatellite Instability-High (MSI-H) Metastatic Colorectal Cancer

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Trial Profile

Colorectal Cancer Metastatic dMMR/MSI-H Immuno-Therapy (COMMIT) Study: A Randomized Phase III Study of mFOLFOX6/Bevacizumab/Atezolizumab Combination Versus Single Agent Atezolizumab in the First-Line Treatment of Patients With Deficient DNA Mismatch Repair (dMMR)/Microsatellite Instability-High (MSI-H) Metastatic Colorectal Cancer

Status: Recruiting
Phase of Trial: Phase III

Latest Information Update: 30 Oct 2024

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At a glance

  • Drugs Atezolizumab (Primary) ; Bevacizumab (Primary) ; Fluorouracil; Folinic acid; Oxaliplatin
  • Indications Adenocarcinoma; Colon cancer; Colorectal cancer; Rectal cancer
  • Focus Therapeutic Use
  • Acronyms COMMIT
  • Most Recent Events

    • 04 Jun 2024 Study design presented at the 60th Annual Meeting of the American Society of Clinical Oncology.
    • 20 Jan 2024 Trial design, presented at the 2024 Gastrointestinal Cancers Symposium
    • 30 Mar 2023 Planned number of patients changed from 231 to 120.

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