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A Multicentre, Late Phase Clinical Trial to Establish the Efficacy and Safety of Repeat Dosing of Autologous Endothelial Progenitor Cells (EPCs) Transfected With Human Endothelial NO-synthase (eNOS) in Patients With Pulmonary Arterial Hypertension (PAH) on Top of Conventional Treatments

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Trial Profile

A Multicentre, Late Phase Clinical Trial to Establish the Efficacy and Safety of Repeat Dosing of Autologous Endothelial Progenitor Cells (EPCs) Transfected With Human Endothelial NO-synthase (eNOS) in Patients With Pulmonary Arterial Hypertension (PAH) on Top of Conventional Treatments

Status: Active, no longer recruiting
Phase of Trial: Phase II/III

Latest Information Update: 31 Dec 2024

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At a glance

  • Drugs Endothelial stem cell therapy (Primary)
  • Indications Pulmonary arterial hypertension
  • Focus Therapeutic Use
  • Acronyms SAPPHIRE
  • Sponsors Northern Therapeutics

    • Most Recent Events

    • 18 Nov 2024 Results assessing the effects of autologous, angiogenic endothelial progenitor cells (EPCs) transfected with endothelial NO synthase (eNOS) in PAH patients receiving available standard-of-care therapies, presented at the American Heart Association Scientific Sessions 2024.
    • 09 Jan 2023 Planned End Date changed from 1 Dec 2025 to 1 Dec 2023.
    • 09 Jan 2023 Planned primary completion date changed from 1 Dec 2025 to 1 Dec 2023.

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