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A Phase I Trial of CBT-1 in Combination With Doxorubicin in Patients With Locally Advanced or Metastatic, Unresectable Sarcomas Previously to Have Progressed on 150 mg/m2 or Less of Doxorubicin

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A Phase I Trial of CBT-1 in Combination With Doxorubicin in Patients With Locally Advanced or Metastatic, Unresectable Sarcomas Previously to Have Progressed on 150 mg/m2 or Less of Doxorubicin

Status: Recruiting
Phase of Trial: Phase I

Latest Information Update: 05 Nov 2021

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At a glance

  • Drugs Doxorubicin (Primary) ; Tetrandrine (Primary)
  • Indications Sarcoma; Soft tissue sarcoma
  • Focus Adverse reactions
  • Sponsors CBA Pharma

    • Most Recent Events

    • 04 Jun 2019 Trial design presented at the 55th Annual Meeting of the American Society of Clinical Oncology
    • 04 Jun 2019 To date, Cohorts 1 (50 mg CBT-1) and 2 (100 mg CBT-1) have been completed with one DLT of grade 4 neutropenia lasting longer than 7 days in Cohort 1. Enrollment to Cohort 3 began December 2018 as per trial design presented at the 55th Annual Meeting of the American Society of Clinical Oncology
    • 04 Apr 2018 Status changed from not yet recruiting to recruiting.

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