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ImmunoModulation by the Combination of Ipilimumab and Nivolumab Neoadjuvant to Surgery In Advanced Or Recurrent Head and Neck Carcinoma. Subtitle: Hypoxia as a Determinant for the Effect of Nivolumab With or Without Ipilimumab on Intra-tumoral T Cell Capacity

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ImmunoModulation by the Combination of Ipilimumab and Nivolumab Neoadjuvant to Surgery In Advanced Or Recurrent Head and Neck Carcinoma. Subtitle: Hypoxia as a Determinant for the Effect of Nivolumab With or Without Ipilimumab on Intra-tumoral T Cell Capacity

Status: Completed
Phase of Trial: Phase I/II

Latest Information Update: 04 May 2022

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At a glance

  • Drugs Ipilimumab (Primary) ; Nivolumab (Primary)
  • Indications Head and neck cancer; Hypopharyngeal cancer; Laryngeal cancer; Mouth neoplasm; Oropharyngeal cancer; Squamous cell cancer
  • Focus Adverse reactions; Therapeutic Use
  • Acronyms IMCISION

    • Most Recent Events

    • 01 May 2022 Results assessing the utility of [18F]FDG-PET as an imaging biomarker for pathological response early upon neoadjuvant immune checkpoint blockade in patients with head and neck squamous cell carcinoma published in the European Journal of Nuclear Medicine and Molecular Imaging
    • 12 Feb 2021 Status changed from recruiting to completed.
    • 21 Sep 2020 Results (n=32) assessing presented at the 45th European Society for Medical Oncology Congress.

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