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A Phase 1, Open-Label, Dose-Escalation and Cohort Expansion First-in-Human Study of the Safety, Tolerability, Activity and Pharmacokinetics of REGN3767 (Anti-LAG-3 mAb) Administered Alone or in Combination With REGN2810 (Anti-PD-1 mAb) in Patients With Advanced Malignancies

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Trial Profile

A Phase 1, Open-Label, Dose-Escalation and Cohort Expansion First-in-Human Study of the Safety, Tolerability, Activity and Pharmacokinetics of REGN3767 (Anti-LAG-3 mAb) Administered Alone or in Combination With REGN2810 (Anti-PD-1 mAb) in Patients With Advanced Malignancies

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 11 Sep 2024

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At a glance

  • Drugs Cemiplimab (Primary) ; Fianlimab (Primary)
  • Indications Cancer; Head and neck cancer; Lymphoma; Malignant melanoma; Squamous cell cancer
  • Focus Adverse reactions; First in man; Pharmacokinetics; Therapeutic Use
  • Sponsors Regeneron Pharmaceuticals

    • Most Recent Events

    • 09 Sep 2024 According to a Regeneron Pharmaceuticals media release, company will present two-year results evaluating the investigational combination of LAG-3 inhibitor fianlimab and Libtayo (cemiplimab) in adults with advanced melanoma across three independent expansion cohorts of a first-in-human, multi-cohort trial in European Society for Medical Oncology (ESMO) Annual Meeting (September 13-17).
    • 04 Jun 2024 Results (as of 04 Oct 2023 data cut off)presented at the 60th Annual Meeting of the American Society of Clinical Oncology
    • 29 Apr 2024 Status changed from active, no longer recruiting to completed.

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