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A Randomized, Double-blind, Placebo-Controlled, Dose-Ranging Phase 2 Study of ISIS 681257 (AKCEA-APO(a)-LRx) Administered Subcutaneously to Patients With Hyperlipoproteinemia(a) and Established Cardiovascular Disease (CVD)

Trial Profile

A Randomized, Double-blind, Placebo-Controlled, Dose-Ranging Phase 2 Study of ISIS 681257 (AKCEA-APO(a)-LRx) Administered Subcutaneously to Patients With Hyperlipoproteinemia(a) and Established Cardiovascular Disease (CVD)

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 31 Mar 2022

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At a glance

  • Drugs Pelacarsen (Primary)
  • Indications Hyperlipoproteinaemia
  • Focus Adverse reactions; Pharmacokinetics
  • Sponsors Akcea Therapeutics; Ionis Pharmaceuticals

Most Recent Events

  • 22 Mar 2022 Results published in the Journal of the American College of Cardiology
  • 08 Apr 2020 Results (n=32) assessing gene expression profile of circulating monocytes of healthy individuals and CVD patients, both with elevated Lp(a) in two studies (AKCEA-APO(a)-LRx study (NCT03070782) and the ANITSCHKOW study (NCT02729025)), published in the European Heart Journal.
  • 02 Jan 2020 Results published in Akcea Therapeutics media release

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