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Phase I/Ib Study of Concurrent Intravenous and Intrathecal Nivolumab for Melanoma and Lung Cancer Patients With Leptomeningeal Disease (LMD)

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Trial Profile

Phase I/Ib Study of Concurrent Intravenous and Intrathecal Nivolumab for Melanoma and Lung Cancer Patients With Leptomeningeal Disease (LMD)

Status: Active, no longer recruiting
Phase of Trial: Phase I

Latest Information Update: 19 Jul 2024

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At a glance

  • Drugs Nivolumab (Primary) ; Nivolumab
  • Indications Acral lentiginous melanoma; Malignant melanoma; Meningeal carcinomatosis; Non-small cell lung cancer; Uveal melanoma
  • Focus Adverse reactions; First in man; Therapeutic Use

    • Most Recent Events

    • 24 Oct 2023 Updated safety and efficacy results for the escalation and expansion cohorts were presented at the 48th European Society for Medical Oncology Congress
    • 31 Jul 2023 Planned End Date changed from 30 Dec 2023 to 30 Dec 2025.
    • 31 Jul 2023 Planned primary completion date changed from 30 Dec 2023 to 30 Dec 2025.

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