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A Phase 1/2a Open-label, Multicenter, Dose Escalation and Dose Expansion Study of the Safety, Tolerability, and Pharmacokinetics of HPN424 in Patients With Advanced Prostate Cancer Refractory to Androgen Therapy

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Trial Profile

A Phase 1/2a Open-label, Multicenter, Dose Escalation and Dose Expansion Study of the Safety, Tolerability, and Pharmacokinetics of HPN424 in Patients With Advanced Prostate Cancer Refractory to Androgen Therapy

Status: Discontinued
Phase of Trial: Phase I/II

Latest Information Update: 19 Feb 2024

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At a glance

  • Drugs HPN 424 (Primary)
  • Indications Adenocarcinoma; Prostate cancer
  • Focus Adverse reactions; First in man; Therapeutic Use
  • Sponsors Harpoon Therapeutics

    • Most Recent Events

    • 18 Jan 2024 Status changed from active, no longer recruiting to discontinued. (Decision not to continue to the expansion portion of the study.)
    • 27 Jan 2023 According to ClinicalTrials.gov record, protocol has been amended to increase patient number from 40 to 110, Trial focus has also been changed to AR and TU. Intervention will be sequential.
    • 20 Jan 2023 Planned number of patients changed from 40 to 110.

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