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A Phase III, Randomized, Multicenter, Open-Label, Comparative Study to Determine the Efficacy of Durvalumab or Durvalumab and Tremelimumab in Combination With Platinum-Based Chemotherapy for the First-Line Treatment in Patients with Extensive Disease Small-Cell Lung Cancer (SCLC) (CASPIAN)

Trial Profile

A Phase III, Randomized, Multicenter, Open-Label, Comparative Study to Determine the Efficacy of Durvalumab or Durvalumab and Tremelimumab in Combination With Platinum-Based Chemotherapy for the First-Line Treatment in Patients with Extensive Disease Small-Cell Lung Cancer (SCLC) (CASPIAN)

Status: Active, no longer recruiting
Phase of Trial: Phase III

Latest Information Update: 29 Nov 2019

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At a glance

  • Drugs Durvalumab (Primary) ; Tremelimumab (Primary) ; Carboplatin; Cisplatin; Etoposide
  • Indications Brain metastases; Small cell lung cancer
  • Focus Therapeutic Use
  • Acronyms CASPIAN
  • Sponsors AstraZeneca
  • Most Recent Events

    • 29 Nov 2019 According to an AstraZeneca media release, the company announced that the US Food and Drug Administration (FDA) has accepted a supplemental Biologics License Application (sBLA) and granted Priority Review for Imfinzi (durvalumab) for the treatment of patients with previously untreated extensive-stage small cell lung cancer (SCLC) based on the results of this study.
    • 04 Oct 2019 Results published in the THE LANCET
    • 24 Sep 2019 Planned primary completion date changed from 30 Sep 2019 to 30 Dec 2019.
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