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An Open Label, Multicenter, Single Arm Phase II Study to Evaluate the Activity and Tolerability of the Novel mTOR Inhibitor, MLN0128 (TAK-228), in Patients With Locally Advanced or Metastatic Transitional Cell Carcinoma of the Urothelial Tract Whose Tumors Harbor a TSC1 and/or a TSC2 Mutation

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An Open Label, Multicenter, Single Arm Phase II Study to Evaluate the Activity and Tolerability of the Novel mTOR Inhibitor, MLN0128 (TAK-228), in Patients With Locally Advanced or Metastatic Transitional Cell Carcinoma of the Urothelial Tract Whose Tumors Harbor a TSC1 and/or a TSC2 Mutation

Status: Discontinued
Phase of Trial: Phase II

Latest Information Update: 18 Nov 2024

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At a glance

  • Drugs Sapanisertib (Primary)
  • Indications Bladder cancer; Carcinoma
  • Focus Therapeutic Use

    • Most Recent Events

    • 13 Nov 2024 Planned End Date changed from 30 Jun 2024 to 11 Nov 2025.
    • 08 Jul 2023 Planned End Date changed from 30 Jun 2023 to 30 Jun 2024.
    • 08 Jul 2023 Planned primary completion date changed from 30 Jun 2023 to 30 Jun 2024.

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