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A phase III randomized open-label multi-center study of ruxolitinib vs. best available therapy in patients with corticosteroid-refractory chronic graft versus host disease after allogenic stem cell transplantation (REACH 3)

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A phase III randomized open-label multi-center study of ruxolitinib vs. best available therapy in patients with corticosteroid-refractory chronic graft versus host disease after allogenic stem cell transplantation (REACH 3)

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 16 Jan 2024

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At a glance

  • Drugs Ruxolitinib (Primary) ; Everolimus; Ibrutinib; Imatinib; Infliximab; Methotrexate; Mycophenolate mofetil; Pentostatin; Prednisone; Rituximab; Sirolimus
  • Indications Graft-versus-host disease
  • Focus Registrational; Therapeutic Use
  • Acronyms REACH3
  • Sponsors Incyte Corporation; Novartis; Novartis Healthcare

    • Most Recent Events

    • 12 Dec 2023 Results assessing the final, long-term efficacy and safety outcomes from REACH3, were presented at the 65th American Society of Hematology Annual Meeting and Exposition.
    • 28 Oct 2023 Results published in the Bone Marrow Transplantation
    • 21 Mar 2023 Results of post hoc analysis from REACH2 and REACH3 trials assessing the ruxolitinib efficacy in patients with dermatologic manifestations of graft-versus-host disease, presented at the American Academy of Dermatology annual Meeting 2023.

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