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An Open-label Drug Interaction Study in Healthy Subjects to Evaluate the Effect of Oral Doses of JNJ-54175446 on the Inhibition of Cytochrome P450 CYP3A4, CYP2C9, CYP1A2 and CYP2D6 Activity and the Induction of CYP2B6 and CYP2C19 Activity Using a Multiple Probe Substrate Cocktail

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Trial Profile

An Open-label Drug Interaction Study in Healthy Subjects to Evaluate the Effect of Oral Doses of JNJ-54175446 on the Inhibition of Cytochrome P450 CYP3A4, CYP2C9, CYP1A2 and CYP2D6 Activity and the Induction of CYP2B6 and CYP2C19 Activity Using a Multiple Probe Substrate Cocktail

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 17 Sep 2021

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At a glance

  • Drugs JNJ 54175446 (Primary) ; Bupropion; Caffeine; Dextromethorphan; Midazolam; Omeprazole; Warfarin
  • Indications Major depressive disorder
  • Focus Pharmacokinetics
  • Sponsors Janssen Research & Development

    • Most Recent Events

    • 07 Jun 2017 Status changed from recruiting to completed.
    • 03 Apr 2017 Status changed from not yet recruiting to recruiting.
    • 13 Mar 2017 Planned initiation date changed from 1 Feb 2017 to 16 Mar 2017.
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