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Efficacy and Safety of Semaglutide Once-weekly Versus Sitagliptin Once-daily as add-on to Metformin in Subjects With Type 2 Diabetes. A 30-week Randomised, Double-blind, Double-dummy, Active-controlled, Parallel-group, Multi-centre and Multi-national Trial

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Trial Profile

Efficacy and Safety of Semaglutide Once-weekly Versus Sitagliptin Once-daily as add-on to Metformin in Subjects With Type 2 Diabetes. A 30-week Randomised, Double-blind, Double-dummy, Active-controlled, Parallel-group, Multi-centre and Multi-national Trial

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 23 Jan 2024

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At a glance

  • Drugs Semaglutide (Primary) ; Sitagliptin
  • Indications Type 2 diabetes mellitus
  • Focus Registrational; Therapeutic Use
  • Acronyms SUSTAIN; SUSTAIN - CHINA MRCT
  • Sponsors Novo Nordisk

    • Most Recent Events

    • 18 Jan 2024 Results of post hoc analysis (n=110) assessing Efficacy and Safety of Once-Weekly Semaglutide Versus Once-Daily Sitagliptin as Metformin Add-on in a Korean Population with Type 2 Diabetes published in the Diabetes Therapy
    • 09 Nov 2022 Results assessing the long-term cost-effectiveness of once-weekly semaglutide 0.5mg and 1.0mg versus Polyethylene Glycol Loxenatide, 0.2mg (a Chinese self-developed once-weekly GLP-1RA) among patients with type 2 diabetes in Chinese setting includes baseline cohort characteristics were sourced from the SUSTAIN China clinical trial, presented at the 25th Annual European Congress of the International Society for Pharmacoeconomics and Outcomes Research.
    • 16 Jun 2020 Results presented at the 80th Annual Scientific Sessions of the American Diabetes Association

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