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Nivolumab and Ipilimumab Treatment in Prostate Cancer With an Immunogenic Signature

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Trial Profile

Nivolumab and Ipilimumab Treatment in Prostate Cancer With an Immunogenic Signature

Status: Active, no longer recruiting
Phase of Trial: Phase II

Latest Information Update: 10 Jul 2024

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At a glance

  • Drugs Ipilimumab (Primary) ; Nivolumab (Primary)
  • Indications Adenocarcinoma; Prostate cancer
  • Focus Therapeutic Use
  • Acronyms NEPTUNES

    • Most Recent Events

    • 04 Jun 2024 Results(Between May 2018 and June 2022 , n=119) reporting a phase 2 trial of two different dose schedules for nivolumab (NIVO) + ipilimumab (IPI) in patients and expecting dose schedule and biomarker should now be tested in a phase 3 clinical trial, presented at the 60th Annual Meeting of the American Society of Clinical Oncology
    • 28 Jun 2022 The protocol was amended to add a new cohort of patients receiving Nivolumab 3 mg/kg and ipilimumab 1 mg/kg every three weeks for a maximum of 4 doses with a 3 week gap after last combination dose, according to ClinicalTrials.gov record. Accordingly, the patient number was changed to 380.
    • 28 Jun 2022 Planned End Date changed from 1 Jul 2025 to 1 Jun 2027.

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