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Donor-Derived Very-Rapid Manufactured CD19-Specific T Cells for Lymphoid Malignancies After Allogeneic Hematopoietic Stem-Cell Transplantation

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Trial Profile

Donor-Derived Very-Rapid Manufactured CD19-Specific T Cells for Lymphoid Malignancies After Allogeneic Hematopoietic Stem-Cell Transplantation

Status: Discontinued
Phase of Trial: Phase I

Latest Information Update: 25 Aug 2022

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At a glance

  • Drugs Anti CD19 chimeric antigen receptor T cell therapy Alaunos Therapeutics (Primary) ; Cetuximab; Cyclophosphamide; Fludarabine
  • Indications B-cell lymphoma; Chronic lymphocytic leukaemia; Diffuse large B cell lymphoma; Follicular lymphoma; Leukaemia; Mantle-cell lymphoma; Non-Hodgkin's lymphoma; Precursor B-cell lymphoblastic leukaemia-lymphoma
  • Focus Adverse reactions

    • Most Recent Events

    • 28 May 2021 Status changed from recruiting to discontinued.
    • 09 Jul 2020 According to a ZIOPHARM Oncology media release, in this trial, the Company utilizes its non-viral Sleeping Beauty genetic engineering technology to infuse CAR-T the day after electroporation. Ziopharms RPM CD19-specific CAR-T therapy results from the stable, non-viral insertion of DNA into the genome of resting T cells to co-express the chimeric antigen receptor (CAR), membrane-bound IL-15 (mbIL15) and a safety switch.
    • 09 Jul 2020 Status changed from not yet recruiting to recruiting, according to a ZIOPHARM Oncology media release.

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