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Effects of the PCSK9 Antibody AliroCuMab on Coronary Atherosclerosis in PatieNts With Acute Myocardial Infarction: A Serial, Multivessel, Intravascular Ultrasound, Near-Infrared Spectroscopy And Optical Coherence Tomography Imaging Study

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Trial Profile

Effects of the PCSK9 Antibody AliroCuMab on Coronary Atherosclerosis in PatieNts With Acute Myocardial Infarction: A Serial, Multivessel, Intravascular Ultrasound, Near-Infrared Spectroscopy And Optical Coherence Tomography Imaging Study

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 09 Oct 2023

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At a glance

  • Drugs Alirocumab (Primary)
  • Indications Coronary arteriosclerosis; Myocardial infarction; Stroke
  • Focus Therapeutic Use
  • Acronyms PACMAN-AMI
  • Most Recent Events

    • 28 Aug 2023 Results assessing the influence of aggressive LDL-lowering on neutrophil activation, and immune cell gene expression of pro-inflammatory markers in a subset of the PACMAN-AMI cohort, presented at the ESC Congress 2023 - Annual Congress of the European Society of Cardiology.
    • 28 Aug 2023 Results assessing the effects of the PCSK9 inhibitor alirocumab on QFR and 3D-Quantitative Coronary Angiography (3D-QCA) DS% in non-infarct-related arteries (non-IRA) among acute myocardial infarction (AMI) patients presented at the ESC Congress 2023 - Annual Congress of the European Society of Cardiology
    • 20 Aug 2023 Results (n=84) assessing investigate rates, determinants and prognostic implications of triple regression in patients presenting with acute myocardial infarction (AMI) and treated with high-intensity lipid-lowering therapy published in the Journal of the American College of Cardiology
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