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A Phase 1 Dose Escalation and Cohort Expansion Study of TSR-033, an Anti-LAG-3 Monoclonal Antibody, Alone and in Combination With an Anti-PD-1 in Patients With Advanced Solid Tumors

Trial Profile

A Phase 1 Dose Escalation and Cohort Expansion Study of TSR-033, an Anti-LAG-3 Monoclonal Antibody, Alone and in Combination With an Anti-PD-1 in Patients With Advanced Solid Tumors

Status: Recruiting
Phase of Trial: Phase I

Latest Information Update: 30 Oct 2019

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At a glance

  • Drugs Dostarlimab (Primary) ; TSR 033 (Primary)
  • Indications Colorectal cancer; Solid tumours
  • Focus Adverse reactions; First in man; Therapeutic Use
  • Acronyms CITRINO
  • Sponsors TESARO
  • Most Recent Events

    • 23 Oct 2019 Planned number of patients changed from 260 to 200.
    • 09 Nov 2018 According to a TESARO media release, preliminary results (n=30) of the monotherapy dose-escalation portion from this study, were presented at the 2018 Annual Meeting of the Society for Immunotherapy of Cancer (SITC) Conference in Washington, D.C.
    • 09 Nov 2018 Preliminary results (n=30) of the monotherapy dose-escalation portion from this study presented in a TESARO media release.
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