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A Randomized, Double-blind, Placebo-controlled Phase II Multi-Center Evaluation to Assess the Safety and Tolerability of DM199 Administered Intravenously and Subcutaneously in Subjects With Acute Ischemic Stroke

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Trial Profile

A Randomized, Double-blind, Placebo-controlled Phase II Multi-Center Evaluation to Assess the Safety and Tolerability of DM199 Administered Intravenously and Subcutaneously in Subjects With Acute Ischemic Stroke

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 19 Nov 2024

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At a glance

Most Recent Events

  • 13 Nov 2024 According to a DiaMedica Therapeutics media release, the subgroup of patients who received tPA (n=20) prior to enrollment showed the highest response rate of any group, with these patients receiving DM199 or placebo an average of 13.5 hours post-tPA administration, indicating that the participants did have a persistent neurological deficit prior to randomization. The Company further notes that including these patients has the potential to significantly accelerate enrollment.
  • 14 Mar 2022 According to a DiaMedica Therapeutics media release, data from this study will be presented at the American Heart Association 2022 International Stroke Conference.
  • 11 Feb 2022 Results of post-hoc analysis assessing the effect of DM199 on the rate of stroke recurrence during a 90-day follow-up. Stroke recurrence after a primary stroke is associated with longer hospitalization and increased neurologic disability and death, presented at the International Stroke Conference 2022.

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