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A Multicenter, Phase 1, Open-Label, Dose-Escalation Study of the Safety, Tolerability and Pharmacokinetics of ABBV-368 as a Single Agent and Combination in Subjects With Locally Advanced or Metastatic Solid Tumors

Trial Profile

A Multicenter, Phase 1, Open-Label, Dose-Escalation Study of the Safety, Tolerability and Pharmacokinetics of ABBV-368 as a Single Agent and Combination in Subjects With Locally Advanced or Metastatic Solid Tumors

Recruiting
Phase of Trial: Phase I

Latest Information Update: 28 Dec 2018

At a glance

  • Drugs ABBV 181 (Primary) ; ABBV 368 (Primary)
  • Indications Advanced breast cancer; Bladder cancer; Carcinoma; Cholangiocarcinoma; Head and neck cancer; Hypopharyngeal cancer; Laryngeal cancer; Malignant melanoma; Mesothelioma; Non-small cell lung cancer; Oropharyngeal cancer; Ovarian cancer; Renal cell carcinoma; Small cell lung cancer; Solid tumours; Squamous cell cancer
  • Focus Adverse reactions; First in man; Pharmacokinetics
  • Sponsors AbbVie
  • Most Recent Events

    • 28 Sep 2018 Planned number of patients changed from 150 to 170.
    • 28 Sep 2018 Planned End Date changed from 8 Jul 2020 to 25 Mar 2020.
    • 27 Jul 2018 Planned number of patients changed from 100 to 150.
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