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Safety and Activity of Programmed Cell Death-1 Knockout Engineered T Cells in Patients With Previously Treated Advanced Esophageal Squamous Cell Carcinoma: An Open-label, Single-arm Phase 1 Study

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Safety and Activity of Programmed Cell Death-1 Knockout Engineered T Cells in Patients With Previously Treated Advanced Esophageal Squamous Cell Carcinoma: An Open-label, Single-arm Phase 1 Study

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 05 Nov 2021

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At a glance

  • Drugs PD-1 knockout T-cells (Primary) ; Cyclophosphamide; Hydrocortisone; Interleukin-2
  • Indications Oesophageal cancer; Squamous cell cancer
  • Focus Therapeutic Use

    • Most Recent Events

    • 10 Jun 2019 Status changed from recruiting to completed.
    • 05 Jun 2018 Results (n=21) assessing safety presented at the 54th Annual Meeting of the American Society of Clinical Oncology
    • 22 Mar 2017 New trial record

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