Trial Profile

Neurodevelopmental Outcome After Standard Dose Sevoflurane Versus Low-dose Sevoflurane/Dexmedetomidine/Remifentanil Anaesthesia in Young Children- The TREX Trial

Status: Active, no longer recruiting

Phase of Trial: Phase III

Latest Information Update: 24 Sep 2026

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At a glance

Drugs Dexmedetomidine (Primary) ; Remifentanil (Primary) ; Sevoflurane (Primary)
Indications Anaesthesia
Focus Therapeutic Use
Acronyms The TREX Trial

10 Sep 2026 Planned End Date changed from 1 Jun 2026 to 1 Oct 2026.
10 Sep 2026 Planned primary completion date changed from 1 Mar 2026 to 1 Oct 2026.
01 Dec 2024 Results secondary analyses comparing incidence of intraoperative hypotension and bradycardia, postoperative pain, time to recovery, need for treatment of intraoperative hypotension and bradycardia, incidence of light anesthesia and need for treatment, need for postoperative pain medications, and morbidity and mortality outcomes at 5 days between the two arms published in the Anesthesiology.

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