Trial Profile

A Phase I Trial of CD19-Targeted EGFRt/19-28z/4-1BBL "Armored" Chimeric Antigen Receptor (CAR) Modified T Cells in Patients With Relapsed or Refractory CD19+ Hematologic Malignancies

Status: Active, no longer recruiting

Phase of Trial: Phase I

Latest Information Update: 23 Apr 2026

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At a glance

Drugs Anti CD19 chimeric antigen receptor T cell therapy Juno Therapeutics (Primary)
Indications B-cell lymphoma; Burkitt's lymphoma; Chronic lymphocytic leukaemia; Chronic myeloid leukaemia; Diffuse large B cell lymphoma; Follicular lymphoma; Haematological malignancies; Marginal zone B-cell lymphoma; Non-Hodgkin's lymphoma; Precursor cell lymphoblastic leukaemia-lymphoma; Waldenstrom's macroglobulinaemia
Focus Adverse reactions; First in man

07 Apr 2026 Planned End Date changed from 1 Mar 2026 to 1 Mar 2027.
07 Apr 2026 Planned primary completion date changed from 1 Mar 2026 to 1 Mar 2027.
02 Apr 2025 Planned End Date changed from 1 Mar 2025 to 1 Mar 2026.

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