Trial Profile

Phase I Study of Cellular Immunotherapy Using T Cells Lentivirally Transduced to Express a CD123-Specific, Hinge-Optimized, CD28-Costimulatory Chimeric Antigen Receptor and a Truncated EGFR for Patients With CD123+ Relapsed/Refractory Acute Myeloid Leukemia and Persistent/Recurrent Blastic Plasmacytoid Dendritic Cell Neoplasm

Status: Active, no longer recruiting

Phase of Trial: Phase I

Latest Information Update: 24 Jun 2025

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At a glance

Drugs MB 102 Mustang Bio (Primary) ; Cyclophosphamide; Fludarabine
Indications Acute myeloid leukaemia; Blastic plasmacytoid dendritic cell neoplasm
Focus Adverse reactions; First in man; Therapeutic Use

17 Jun 2025 Planned End Date changed from 15 Dec 2024 to 18 Aug 2025.
17 Jun 2025 Planned primary completion date changed from 15 Dec 2024 to 18 Aug 2025.
29 Jan 2024 Planned End Date changed from 15 Dec 2023 to 15 Dec 2024.

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