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A Phase Ib Trial Evaluating the Safety of Copanlisib, Letrozole, and Palbociclib in Metastatic Breast Cancer and Phase II Trial Comparing the Molecular Effects of Neoadjuvant Copanlisib in Combination With Palbociclib and Letrozole, vs. Copanlisib With Letrozole, vs. Palbociclib With Letrozole for Patients With Hormone Receptor Positive, HER2 Normal Breast Cancer

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A Phase Ib Trial Evaluating the Safety of Copanlisib, Letrozole, and Palbociclib in Metastatic Breast Cancer and Phase II Trial Comparing the Molecular Effects of Neoadjuvant Copanlisib in Combination With Palbociclib and Letrozole, vs. Copanlisib With Letrozole, vs. Palbociclib With Letrozole for Patients With Hormone Receptor Positive, HER2 Normal Breast Cancer

Status: Discontinued
Phase of Trial: Phase I/II

Latest Information Update: 28 Sep 2022

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At a glance

  • Drugs Copanlisib (Primary) ; Letrozole (Primary) ; Palbociclib (Primary)
  • Indications Advanced breast cancer; Early breast cancer
  • Focus Adverse reactions; Therapeutic Use

    • Most Recent Events

    • 04 Apr 2022 Status changed from active, no longer recruiting to discontinued.
    • 07 Oct 2021 Planned End Date changed from 2 Aug 2022 to 2 Aug 2023.
    • 07 Oct 2021 Planned primary completion date changed from 2 Aug 2021 to 2 Aug 2022.

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