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A Phase 3, Multicenter, Randomized, Open Label Study to Compare the Efficacy and Safety of BB2121 Versus Standard Regimens in Subjects with Relapsed and Refractory Multiple Myeloma (RRMM) (KarMMa-3)

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A Phase 3, Multicenter, Randomized, Open Label Study to Compare the Efficacy and Safety of BB2121 Versus Standard Regimens in Subjects with Relapsed and Refractory Multiple Myeloma (RRMM) (KarMMa-3)

Status: Active, no longer recruiting
Phase of Trial: Phase III

Latest Information Update: 03 Sep 2024

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At a glance

  • Drugs Idecabtagene vicleucel (Primary) ; Bortezomib; Bortezomib; Carfilzomib; Daratumumab; Dexamethasone; Dexamethasone; Elotuzumab; Ixazomib; Lenalidomide; Pomalidomide
  • Indications Multiple myeloma
  • Focus Registrational; Therapeutic Use
  • Acronyms KarMMa-3
  • Sponsors Celgene Corporation

    • Most Recent Events

    • 04 Jun 2024 Results assessing 3 prototype models for risk of developing high-grade iAEs after ide-cel infusion, presented at the 60th Annual Meeting of the American Society of Clinical Oncology.
    • 04 Jun 2024 Results assessing pre- and post-tx pt factors and pharmacodynamic biomarkers associated with longer PFS with ide-cel in the treated population , presented at the 60th Annual Meeting of the American Society of Clinical Oncology.
    • 23 May 2024 According to Bristol Myers Squibb media release, the company announced the presentation of data across its oncology and hematology portfolio at the upcoming 2024 American Society of Clinical Oncology (ASCO) Annual Meeting and the European Hematology Association (EHA) 2024 Hybrid Congress.

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