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A Phase IIIB Comparative Trial of Seasonal Vaccination With the Malaria Vaccine RTS,S/AS01, Seasonal Malaria Chemoprevention and of the Two Interventions Combined

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A Phase IIIB Comparative Trial of Seasonal Vaccination With the Malaria Vaccine RTS,S/AS01, Seasonal Malaria Chemoprevention and of the Two Interventions Combined

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 28 Aug 2023

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At a glance

  • Drugs GSK 257049 (Primary) ; Amodiaquine; Hepatitis A vaccine; Pyrimethamine/sulfadoxine; Rabies vaccine
  • Indications Falciparum malaria; Malaria
  • Focus Therapeutic Use
  • Acronyms RTSS-SMC

    • Most Recent Events

    • 22 Aug 2023 According to a malariavaccine path vaccine initiative media release, two-year extension study began in April 2020, when 5048 (94%) of the 5433 children who completed the initial three-year follow-up were re-enrolled.
    • 22 Aug 2023 Results from two-year extension over five years published in a malariavaccine path vaccine initiative media release.
    • 22 Aug 2023 According to a malariavaccine path vaccine initiative media release, final results of this landmark study were published in The Lancet Infectious Diseases.

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