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A Phase 1b/2a Dose-escalation and Safety/Efficacy Evaluation Study of Pexa-Vec (Thymidine Kinase-Deactivated Vaccinia Virus Plus GM-CSF) in Combination With Cemiplimab (REGN2810; Anti-PD-1) in Patients With Metastatic or Unresectable Renal Cell Carcinoma (RCC)

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A Phase 1b/2a Dose-escalation and Safety/Efficacy Evaluation Study of Pexa-Vec (Thymidine Kinase-Deactivated Vaccinia Virus Plus GM-CSF) in Combination With Cemiplimab (REGN2810; Anti-PD-1) in Patients With Metastatic or Unresectable Renal Cell Carcinoma (RCC)

Status: Completed
Phase of Trial: Phase I/II

Latest Information Update: 16 Dec 2024

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At a glance

Most Recent Events

  • 25 Oct 2024 Results assessing the AI-powered Lunit SCOPE IO spatial analyzer to assess TILs in metastatic renal cell carcinoma (mRCC) patients undergoing combination therapy with Pexa-vec and cemiplimab presented at the 36th EORTC-NCI-AACR Symposium on molecular targets and cancer therapeutics
  • 04 Jun 2024 Results assessing the correlation between plasma cytokine/chemokine levels and the efficacy of Pexa-Vec and cemiplimab, proposing that these biomarkers could predict treatment outcomes and contribute to more personalized cancer treatment protocols, presented at the 60th Annual Meeting of the American Society of Clinical Oncology.
  • 27 Mar 2024 Status changed from active, no longer recruiting to completed, according to a SillaJen Biotherapeutics Media Release.

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