A Phase 1b Multi-cohort Study of the Combination of Pembrolizumab (MK-3475) Plus Binimetinib Alone or the Combination of Pembrolizumab Plus Chemotherapy With or Without Binimetinib in Participants With Metastatic Colorectal Cancer (KEYNOTE-651)

Status: Completed

Phase of Trial: Phase I

Latest Information Update: 18 Oct 2024

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At a glance

Drugs Binimetinib (Primary) ; Pembrolizumab (Primary) ; Fluorouracil; Folinic acid; Irinotecan; Oxaliplatin
Indications Colorectal cancer
Focus Adverse reactions
Acronyms KEYNOTE-651
Sponsors Merck Sharp & Dohme Corp.

Most Recent Events

28 Sep 2023 Status changed from active, no longer recruiting to completed.
07 Jun 2022 Results presented at the 58th Annual Meeting of the American Society of Clinical Oncology
07 Jun 2022 According to results presented at the 58th Annual Meeting of the American Society of Clinical Oncology, enrollment in cohort C and E was prematurely closed.

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