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A Phase 1, First-in-human, Oral Single and Multiple Dose-Escalation, Randomized, Double-blinded, Placebo-controlled Study of SYNB1020 in Healthy Adult Volunteers to Evaluate Safety, Tolerability, Dosing, and Pharmacodynamics

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Trial Profile

A Phase 1, First-in-human, Oral Single and Multiple Dose-Escalation, Randomized, Double-blinded, Placebo-controlled Study of SYNB1020 in Healthy Adult Volunteers to Evaluate Safety, Tolerability, Dosing, and Pharmacodynamics

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 22 Jan 2019

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At a glance

  • Drugs SYNB 1020 (Primary)
  • Indications Hyperammonaemia; Inborn urea cycle disorders; Liver cirrhosis
  • Focus Adverse reactions; First in man; Proof of concept
  • Sponsors Synlogic

    • Most Recent Events

    • 16 Jan 2019 According to a Synlogic media release, clinical data from this trial and supporting preclinical data from SYNB1020 were published in Science Translational Medicine Journal.
    • 14 Apr 2018 Results presented at The International Liver Congress 2018
    • 12 Mar 2018 Results published in the Synlogic Media Release

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