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A Multi-Centre Trial Evaluating Efficacy and Safety of Prophylactic Administration of Concizumab in Patients With Severe Haemophilia A Without Inhibitors

Trial Profile

A Multi-Centre Trial Evaluating Efficacy and Safety of Prophylactic Administration of Concizumab in Patients With Severe Haemophilia A Without Inhibitors

Status: Active, no longer recruiting
Phase of Trial: Phase II

Latest Information Update: 06 Nov 2019

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At a glance

  • Drugs Concizumab (Primary) ; Turoctocog alfa
  • Indications Haemophilia A
  • Focus Therapeutic Use
  • Acronyms Explorer 5
  • Sponsors Novo Nordisk
  • Most Recent Events

    • 06 Nov 2019 Results released at the 61st Annual Meeting and Exposition of the American Society of Hematology
    • 06 Nov 2019 Data were used from two clinical studies; Explore 4 (n=16) and Explore 5 (n=30) to assess the addictive effects of combination of concizumab and bypassing agents recombinant activated factor VII (rFVIIa) or activated prothrombin complex concentrate (aPCC), released in 61st Annual Meeting and Exposition of the American Society of Hematology
    • 23 Aug 2019 Results from the main parts (24 weeks) of two phase 2 trials that assessed the efficacy and safety of subcutaneous concizumab administration in patients with HA/HB with inhibitors (explorer4) and in patients with severe HA without inhibitors (explorer5) published in the Blood
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