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A Phase 1 Dose Escalation, Open-Label Study of Venetoclax in Combination With Navitoclax and Chemotherapy in Subjects With Relapsed/Refractory Acute Lymphoblastic Leukemia or Relapsed/Refractory Lymphoblastic Lymphoma

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Trial Profile

A Phase 1 Dose Escalation, Open-Label Study of Venetoclax in Combination With Navitoclax and Chemotherapy in Subjects With Relapsed/Refractory Acute Lymphoblastic Leukemia or Relapsed/Refractory Lymphoblastic Lymphoma

Recruiting
Phase of Trial: Phase I

Latest Information Update: 15 Feb 2019

At a glance

  • Drugs Navitoclax (Primary) ; Venetoclax (Primary) ; Dexamethasone; Pegaspargase; Protein tyrosine kinase inhibitors; Vincristine
  • Indications Precursor cell lymphoblastic leukaemia-lymphoma
  • Focus Adverse reactions; Pharmacokinetics
  • Sponsors AbbVie

    • Most Recent Events

    • 04 Dec 2018 Preliminary Results (n=9) presented at the 60th Annual Meeting and Exposition of the American Society of Hematology
    • 17 Jun 2018 Preliminary efficacy results (n=3) presented at the 23rd Congress of the European Haematology Association
    • 05 Jun 2018 Study design was presented at the 54th Annual Meeting of the American Society of Clinical Oncology. As of Jan 5, 2018, 3 patients were enrolled at dose level one.
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