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A Randomized, Double-Blind, Placebo-Controlled Study, Followed by an Open-Label Extension, to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Ascending Doses of Intrathecally Administered ISIS 814907 in Patients With Mild Alzheimer's Disease

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A Randomized, Double-Blind, Placebo-Controlled Study, Followed by an Open-Label Extension, to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Ascending Doses of Intrathecally Administered ISIS 814907 in Patients With Mild Alzheimer's Disease

Status: Completed
Phase of Trial: Phase I/II

Latest Information Update: 03 Nov 2023

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At a glance

  • Drugs BIIB 080 (Primary)
  • Indications Alzheimer's disease
  • Focus Adverse reactions; First in man
  • Sponsors Ionis Pharmaceuticals

    • Most Recent Events

    • 31 Oct 2023 Results presented in the Biogen Media Release.
    • 30 Oct 2023 Results evaluating the effect of tau synthesis reduction on tau biomarkers in patients with mild AD, published in the JAMA Neurology
    • 25 Oct 2023 Results presented in a Biogen media release.

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