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A Randomized, Double-Blind, Placebo-Controlled Study, Followed by an Open-Label Extension, to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Ascending Doses of Intrathecally Administered ISIS 814907 in Patients With Mild Alzheimer's Disease

Trial Profile

A Randomized, Double-Blind, Placebo-Controlled Study, Followed by an Open-Label Extension, to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Ascending Doses of Intrathecally Administered ISIS 814907 in Patients With Mild Alzheimer's Disease

Status: Recruiting
Phase of Trial: Phase I/II

Latest Information Update: 12 Aug 2019

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At a glance

  • Drugs IONIS MAPTRx (Primary)
  • Indications Alzheimer's disease
  • Focus Adverse reactions; First in man
  • Sponsors Ionis Pharmaceuticals
  • Most Recent Events

    • 17 Apr 2018 According to the Ionis Pharmaceuticals media release, data from this study will be presented at the 2018 American Academy of Neurology Highlight the Broad Potential of Antisense Drugs for Neurological Diseases
    • 20 Jul 2017 Preclinical data along with trial design presented at the Alzheimer's Association International Conference 2017.
    • 19 Jun 2017 New trial record
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