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Assessment of the Efficacy of Bevacizumab in Combination With Folfiri as Second-line Treatment After the Failure of the Cisplatin (or Carboplatin)-Etoposide Combination in Patients Suffering From an Advanced Inoperable Poorly Differentiated Neuroendocrine Carcinoma of an Unknown or Gastroentero-pancreatic Primary Cancer. A Phase 2 Non-comparative Randomized Study

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Assessment of the Efficacy of Bevacizumab in Combination With Folfiri as Second-line Treatment After the Failure of the Cisplatin (or Carboplatin)-Etoposide Combination in Patients Suffering From an Advanced Inoperable Poorly Differentiated Neuroendocrine Carcinoma of an Unknown or Gastroentero-pancreatic Primary Cancer. A Phase 2 Non-comparative Randomized Study

Status: Active, no longer recruiting
Phase of Trial: Phase II

Latest Information Update: 24 Apr 2023

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At a glance

  • Drugs Bevacizumab (Primary) ; Fluorouracil; Folinic acid; Irinotecan; Levofolinic acid
  • Indications Colorectal cancer; Gastric cancer; Neuroendocrine carcinoma; Oesophageal cancer; Pancreatic cancer
  • Focus Therapeutic Use
  • Acronyms BEVANEC; PRODIGE 41-BEVANEC

    • Most Recent Events

    • 02 Feb 2023 Results (Between Sept 5, 2017, and Feb 8, 2022) assessing the efficacy of FOLFIRI plus bevacizumab, and FOLFIRI alone, in patients with advanced neuroendocrine carcinoma, published in the Lancet Oncology.
    • 13 Sep 2022 Status changed from recruiting to active, no longer recruiting, according to Results presented at the 47th European Society for Medical Oncology Congress.
    • 13 Sep 2022 Primary endpoint (Proportion of patients alive) has been met, according to Results presented at the 47th European Society for Medical Oncology Congress.

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