NCI-COG Pediatric MATCH (Molecular Analysis for Therapy Choice) - Phase 2 Subprotocol of Tazemetostat in Patients With Tumors Harboring Alterations in EZH2 or Members of the SWI/SNF Complex
Latest Information Update: 29 Jul 2024
At a glance
- Drugs Tazemetostat (Primary)
- Indications CNS cancer; Ependymoma; Ewing's sarcoma; Langerhans cell histiocytosis; Lung cancer; Neuroblastoma; Non-Hodgkin's lymphoma; Renal cancer; Rhabdoid tumour; Sarcoma; Solid tumours
- Focus Therapeutic Use
- Acronyms Pediatric MATCH
- 26 Sep 2023 Planned End Date changed from 18 Apr 2024 to 22 Sep 2024.
- 25 May 2023 Primary endpoint has not been met. (Objective response rate (ORR), as per published in the Journal of the National Cancer Institute
- 25 May 2023 Results assessing Tazemetostat for Tumors Harboring SMARCB1/SMARCA4 or EZH2 Alterations, published in the Journal of the National Cancer Institute