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NCI-COG Pediatric MATCH (Molecular Analysis for Therapy Choice) - Phase 2 Subprotocol of Tazemetostat in Patients With Tumors Harboring Alterations in EZH2 or Members of the SWI/SNF Complex

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Trial Profile

NCI-COG Pediatric MATCH (Molecular Analysis for Therapy Choice) - Phase 2 Subprotocol of Tazemetostat in Patients With Tumors Harboring Alterations in EZH2 or Members of the SWI/SNF Complex

Status: Active, no longer recruiting
Phase of Trial: Phase II

Latest Information Update: 29 Jul 2024

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At a glance

  • Drugs Tazemetostat (Primary)
  • Indications CNS cancer; Ependymoma; Ewing's sarcoma; Langerhans cell histiocytosis; Lung cancer; Neuroblastoma; Non-Hodgkin's lymphoma; Renal cancer; Rhabdoid tumour; Sarcoma; Solid tumours
  • Focus Therapeutic Use
  • Acronyms Pediatric MATCH
  • Most Recent Events

    • 26 Sep 2023 Planned End Date changed from 18 Apr 2024 to 22 Sep 2024.
    • 25 May 2023 Primary endpoint has not been met. (Objective response rate (ORR), as per published in the Journal of the National Cancer Institute
    • 25 May 2023 Results assessing Tazemetostat for Tumors Harboring SMARCB1/SMARCA4 or EZH2 Alterations, published in the Journal of the National Cancer Institute

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