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A Phase 3, Multicenter, Randomized, Controlled, Open-label Study of VELCADE (Bortezomib) Melphalan-Prednisone (VMP) Compared to Daratumumab in Combination With VMP (D-VMP), in Subjects With Previously Untreated Multiple Myeloma Who Are Ineligible for High-Dose Therapy (Asia Pacific Region)

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Trial Profile

A Phase 3, Multicenter, Randomized, Controlled, Open-label Study of VELCADE (Bortezomib) Melphalan-Prednisone (VMP) Compared to Daratumumab in Combination With VMP (D-VMP), in Subjects With Previously Untreated Multiple Myeloma Who Are Ineligible for High-Dose Therapy (Asia Pacific Region)

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 30 May 2025

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At a glance

  • Drugs Bortezomib (Primary) ; Daratumumab (Primary) ; Daratumumab (Primary) ; Melphalan (Primary) ; Prednisone (Primary)
  • Indications Multiple myeloma
  • Focus Therapeutic Use
  • Acronyms OCTANS
  • Sponsors Janssen Research & Development

Most Recent Events

  • 01 May 2025 Results assessing health-related quality of life with daratumumab, bortezomib, melphalan, and prednisone versus bortezomib, melphalan, and prednisone alone in transplant-ineligible patients with newly diagnosed multiple myeloma were published in the Annals of Hematology.
  • 24 Apr 2024 Status changed from active, no longer recruiting to completed.
  • 27 Feb 2024 Planned End Date changed from 31 May 2024 to 31 Mar 2024.

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