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A Phase I Study of AZD8186 in Combination With Docetaxel in Patients With PTEN Mutated or PIK3CB Mutated Advanced Solid Tumors, Potentially Amenable to Docetaxel

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Trial Profile

A Phase I Study of AZD8186 in Combination With Docetaxel in Patients With PTEN Mutated or PIK3CB Mutated Advanced Solid Tumors, Potentially Amenable to Docetaxel

Status: Active, no longer recruiting
Phase of Trial: Phase I

Latest Information Update: 03 Nov 2025

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At a glance

  • Drugs AZD-8186 (Primary) ; Docetaxel (Primary)
  • Indications Advanced breast cancer; Carcinoma; HER2 negative breast cancer; Prostate cancer; Solid tumours; Triple negative breast cancer
  • Focus Adverse reactions

Most Recent Events

  • 30 Oct 2025 Planned End Date changed from 3 Oct 2025 to 3 Oct 2026.
  • 30 Oct 2024 Planned End Date changed from 22 Sep 2024 to 3 Oct 2025.
  • 26 Sep 2023 Planned End Date changed from 27 Mar 2024 to 22 Sep 2024.

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