A Phase III, Randomized, Double-Blind, Clinical Trial of Pembrolizumab (MK-3475) Plus Chemotherapy (XP or FP) Versus Placebo Plus Chemotherapy (XP or FP) as Neoadjuvant/Adjuvant Treatment for Subjects With Gastric and Gastroesophageal Junction (GEJ) Adenocarcinoma (KEYNOTE-585)
Latest Information Update: 24 Jul 2025
At a glance
- Drugs Pembrolizumab (Primary) ; Capecitabine; Cisplatin; Docetaxel; Fluorouracil; Folinic acid; Oxaliplatin
- Indications Adenocarcinoma; Gastric cancer; Oesophageal cancer
- Focus Adverse reactions; Registrational; Therapeutic Use
- Acronyms KEYNOTE-585; MK-3475-585/KEYNOTE-585
- Sponsors Merck Sharp & Dohme; Merck Sharp & Dohme Corp.
Most Recent Events
- 14 Jul 2025 Status changed from active, no longer recruiting to completed.
- 25 Feb 2025 Planned End Date changed from 17 Feb 2025 to 23 Apr 2025.
- 27 Sep 2024 Planned End Date changed from 27 Jun 2025 to 17 Feb 2025.