Trial Profile

A Phase Ib/II, Open-Label, Multicenter, Randomized Umbrella Study Evaluating The Efficacy And Safety Of Multiple Treatment Combinations In Patients With Metastatic Breast Cancer (Morpheus-panBC)

Status: Recruiting

Phase of Trial: Phase I/II

Latest Information Update: 18 Jun 2025

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At a glance

Drugs Atezolizumab (Primary) ; Bevacizumab (Primary) ; Capecitabine (Primary) ; Cobimetinib (Primary) ; Inavolisib (Primary) ; Ipatasertib (Primary) ; Ladiratuzumab-Vedotin (Primary) ; Selicrelumab (Primary) ; Carboplatin; Eribulin; Gemcitabine; Paclitaxel; Sacituzumab govitecan; Tocilizumab
Indications Advanced breast cancer; Male breast cancer; Triple negative breast cancer
Focus Adverse reactions; Therapeutic Use
Acronyms Morpheus-panBC
Sponsors Genentech; Roche

27 Aug 2024 Planned number of patients changed from 312 to 580.
27 Aug 2024 Planned End Date changed from 3 May 2026 to 3 May 2028.
27 Aug 2024 Planned primary completion date changed from 3 May 2026 to 3 May 2028.

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