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QUILT-3.055: A Phase IIb, Multicohort, Open-Label Study of Combination Immunotherapies in Patients Who Have Previously Received Treatment With PD-1/PD-L1 Immune Checkpoint Inhibitors

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Trial Profile

QUILT-3.055: A Phase IIb, Multicohort, Open-Label Study of Combination Immunotherapies in Patients Who Have Previously Received Treatment With PD-1/PD-L1 Immune Checkpoint Inhibitors

Status: Active, no longer recruiting
Phase of Trial: Phase II

Latest Information Update: 20 Mar 2026

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At a glance

  • Drugs Atezolizumab (Primary) ; Avelumab (Primary) ; Durvalumab (Primary) ; Nivolumab (Primary) ; Nogapendekin alfa inbakicept (Primary) ; PD-L1-t-haNK (Primary) ; Pembrolizumab (Primary)
  • Indications Adenocarcinoma; Cervical cancer; Colorectal cancer; Gastric cancer; Head and neck cancer; Liver cancer; Malignant melanoma; Merkel cell carcinoma; Non-small cell lung cancer; Oesophageal cancer; Renal cell carcinoma; Small cell lung cancer; Solid tumours; Squamous cell cancer; Urogenital cancer
  • Focus Therapeutic Use
  • Acronyms QUILT-3.055
  • Sponsors Altor BioScience Corporation; ImmunityBio

Most Recent Events

  • 17 Feb 2026 According to an ImmunityBio media release, based on the data from this basket trial- the scientific rationale for expanding ANKTIVA into additional tumor types in the CPI relapsed population has been discussed between ImmunityBio and SFDA.
  • 14 Jan 2026 According to an ImmunityBio media release, the Saudi Food and Drug Authority (SFDA) has granted accelerated approval of ANKTIVA (nogapendekin alfa inbakicept) for use in combination with immune checkpoint inhibitors for the treatment of adult patients with metastatic non-small cell lung cancer (NSCLC) whose disease has progressed following standard-of-care therapy.
  • 20 Oct 2025 "Prolongation of Overall Survival (OS) with NAI Therapy by ALC Response" added as one more primary end-point.

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