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ATHENA (A Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase 3 Study in Ovarian Cancer Patients Evaluating Rucaparib and Nivolumab as Maintenance Treatment Following Response to Front-Line Platinum-Based Chemotherapy)

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Trial Profile

ATHENA (A Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase 3 Study in Ovarian Cancer Patients Evaluating Rucaparib and Nivolumab as Maintenance Treatment Following Response to Front-Line Platinum-Based Chemotherapy)

Status: Active, no longer recruiting
Phase of Trial: Phase III

Latest Information Update: 21 Jan 2025

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At a glance

  • Drugs Nivolumab (Primary) ; Rucaparib (Primary)
  • Indications Carcinoma; Fallopian tube cancer; Ovarian cancer; Peritoneal cancer
  • Focus Registrational; Therapeutic Use
  • Acronyms ATHENA; ATHENA-COMBO; ATHENA-MONO
  • Sponsors Clovis Oncology [CEASED]; pharmaand GmbH

Most Recent Events

  • 17 Jan 2025 Protocol has been amended , a new open-label arm has been added , Experimental: Japanese Open-label Safety Cohort
  • 04 Oct 2024 According to pharmaand GmbH media release, the company announced today that the European Commission (EC) has granted marketing authorization for a Type II variation for Rubraca(rucaparib) as a first-line maintenance treatment for all women with advanced ovarian cancer regardless of their BRCA mutation status, who have responded to first-line platinum-based chemotherapy based on result of this trial.
  • 04 Jun 2024 Final safety results of this study presented at the 60th Annual Meeting of the American Society of Clinical Oncology.

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