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The Effect of Multiple Doses of Cenobamate (YKP3089) on the Single Dose Pharmacokinetics of Cytochrome P450 Substrates (Midazolam, Warfarin, Omeprazole and Bupropion) Administered Orally in an Open-label, One-sequence Study in Healthy Subjects

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Trial Profile

The Effect of Multiple Doses of Cenobamate (YKP3089) on the Single Dose Pharmacokinetics of Cytochrome P450 Substrates (Midazolam, Warfarin, Omeprazole and Bupropion) Administered Orally in an Open-label, One-sequence Study in Healthy Subjects

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 25 Sep 2024

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At a glance

  • Drugs Cenobamate (Primary) ; Bupropion; Midazolam; Omeprazole; Warfarin
  • Indications Anxiety disorders; Bipolar disorders; Neuropathic pain; Partial epilepsies
  • Focus Pharmacokinetics
  • Sponsors SK Life Science

    • Most Recent Events

    • 16 Mar 2019 Results assessing the effect of Cenobamate on the single dose pharmacokinetics of multiple CYP450 probes using cocktail approach in healthy subjects, were presented at the 120th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics.
    • 07 Aug 2017 Status changed from active, no longer recruiting to completed.
    • 02 Aug 2017 New trial record

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