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Combination of Targeted Therapy (Encorafenib and Binimetinib) Followed by Combination of Immunotherapy (Ipilimumab and Nivolumab) vs Immediate Combination of Immunotherapy in Patients With Unresectable or Metastatic Melanoma With BRAF V600 Mutation : an EORTC Randomized Phase II Study (EBIN)

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Combination of Targeted Therapy (Encorafenib and Binimetinib) Followed by Combination of Immunotherapy (Ipilimumab and Nivolumab) vs Immediate Combination of Immunotherapy in Patients With Unresectable or Metastatic Melanoma With BRAF V600 Mutation : an EORTC Randomized Phase II Study (EBIN)

Status: Active, no longer recruiting
Phase of Trial: Phase II

Latest Information Update: 29 Jul 2024

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At a glance

  • Drugs Binimetinib (Primary) ; Encorafenib (Primary) ; Ipilimumab (Primary) ; Nivolumab (Primary)
  • Indications Malignant melanoma; Skin cancer
  • Focus Adverse reactions; Therapeutic Use
  • Acronyms EBIN

    • Most Recent Events

    • 04 Jun 2024 Results assessing Combination of encorafenib and binimetinib followed by ipilimumab and nivolumab versus ipilimumab and nivolumab in patients with advanced BRAF-V600E/K-mutated melanoma presented at the 60th Annual Meeting of the American Society of Clinical Oncology
    • 28 May 2024 Planned End Date changed from 1 Feb 2024 to 1 Jan 2027.
    • 02 Nov 2023 Planned primary completion date changed from 1 Apr 2022 to 1 Nov 2023.

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