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Efficacy of a selective MEK (trametinib) and BRAFV600E (dabrafenib) inhibitors associated with radioactive iodine (RAI) for the treatment of refractory metastatic differentiated thyroid cancer with RAS or BRAFV600E mutation

Trial Profile

Efficacy of a selective MEK (trametinib) and BRAFV600E (dabrafenib) inhibitors associated with radioactive iodine (RAI) for the treatment of refractory metastatic differentiated thyroid cancer with RAS or BRAFV600E mutation

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 07 Sep 2023

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At a glance

  • Drugs Dabrafenib (Primary) ; Trametinib (Primary) ; Iodine-131; Thyrotropin alfa
  • Indications Thyroid cancer
  • Focus Therapeutic Use
  • Acronyms MERAIODE
  • Most Recent Events

    • 19 Apr 2023 Results assessing the efficacy and safety of dabrafenib-trametinib-131I for the treatment of radioactive iodine refractory metastatic differentiated thyroid cancer (DTC) with a BRAFp.V600E mutation, published in the Clinical Cancer Research.
    • 03 Jun 2022 Status changed from active, no longer recruiting to completed.
    • 27 Sep 2021 Planned primary completion date changed from 1 Dec 2022 to 18 Nov 2021.
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