Trial Profile

Pilot Study to Evaluate the Safety and Feasibility of Induction of Mixed Chimerism in Sickle Cell Disease Patients With COH-MC-17: a Non-Myeloablative, Conditioning Regimen and CD4+ T-cell-depleted Haploidentical Hematopoietic Transplant

Status: Active, no longer recruiting

Phase of Trial: Phase I

Latest Information Update: 28 Apr 2025

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At a glance

Drugs Antithymocyte globulin (Primary) ; Cyclophosphamide (Primary) ; Pentostatin (Primary) ; Mycophenolate mofetil; Mycophenolate mofetil; Tacrolimus; Tacrolimus
Indications Sickle cell anaemia
Focus Adverse reactions; Therapeutic Use

23 Apr 2025 Planned End Date changed from 7 Mar 2025 to 18 Feb 2026.
23 Apr 2025 Planned primary completion date changed from 7 Mar 2025 to 18 Feb 2026.
18 Feb 2025 Planned End Date changed from 17 Nov 2024 to 7 Mar 2025.

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