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Multi-center Phase I/II Study of NY-ESO-1 T Cell Receptor Gene Transferred T Lymphocytes in Patients With Synovial Sarcoma

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Trial Profile

Multi-center Phase I/II Study of NY-ESO-1 T Cell Receptor Gene Transferred T Lymphocytes in Patients With Synovial Sarcoma

Status: Completed
Phase of Trial: Phase I/II

Latest Information Update: 08 Dec 2023

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At a glance

  • Drugs Mipetresgene autoleucel (Primary) ; Cyclophosphamide
  • Indications Synovial sarcoma
  • Focus Adverse reactions; Pharmacokinetics; Therapeutic Use
  • Sponsors Takara Bio

    • Most Recent Events

    • 05 Dec 2023 Status changed from active, no longer recruiting to completed.
    • 06 Jun 2023 Results assessing safety and the efficacy of gene engineered autologous T cell product with NY-ESO-1 siTCR retroviral vector which expressed affinity-enhanced NY-ESO-1-specific TCR and siRNA to silence endogenous TCR, presented at the 59th Annual Meeting of the American Society of Clinical Oncology.
    • 06 Oct 2020 Planned End Date changed from 31 Jan 2034 to 1 Jan 2034.

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