Trial Profile

A Phase 2 Study of AZD1775, a Wee1 Inhibitor, in Patients With CCNE1 Amplification

Status: Completed

Phase of Trial: Phase II

Latest Information Update: 10 Dec 2025

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At a glance

Drugs Adavosertib (Primary)
Indications Advanced breast cancer; Carcinoma; Cholangiocarcinoma; Endometrial cancer; Gallbladder cancer; Germ cell and embryonal neoplasms; Germ cell cancer; Malignant melanoma; Oesophageal cancer; Ovarian cancer; Prostate cancer; Sarcoma; Solid tumours; Urogenital cancer
Focus Therapeutic Use

Most Recent Events

26 Oct 2025 Results presented at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics 2025
04 Mar 2023 Status changed from suspended to completed.
05 Dec 2022 Results (n=30) assess the antitumor activity of adavosertib in patients with CCNE1-amplified, advanced refractory solid tumors published in the Journal of Clinical Oncology

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