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A Phase 2, Multicenter, Open-Label Study to Assess PK/PD of SEG101 (Crizanlizumab), With or Without Hydroxyurea/Hydroxycarbamide, in Sickle Cell Patients With Vaso-Occlusive Crisis

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Trial Profile

A Phase 2, Multicenter, Open-Label Study to Assess PK/PD of SEG101 (Crizanlizumab), With or Without Hydroxyurea/Hydroxycarbamide, in Sickle Cell Patients With Vaso-Occlusive Crisis

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 26 Apr 2024

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At a glance

  • Drugs Crizanlizumab (Primary)
  • Indications Vaso-occlusive crisis
  • Focus Pharmacodynamics; Pharmacokinetics
  • Acronyms SOLACE-adults
  • Sponsors Novartis Pharmaceuticals

    • Most Recent Events

    • 12 Dec 2023 Final interim results presented at the 65th American Society of Hematology Annual Meeting and Exposition
    • 12 Dec 2023 Results of pooled analysis from studies (NCT0189536, NCT03264989, NCT03474965 and NCT03814746 )in patients with SCD, presented at 65th Annual Meeting and Exposition of the American Society of Hematology.
    • 18 Sep 2023 Status changed from active, no longer recruiting to completed.

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